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Saturday, March 31, 2012
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'Game of Thrones' plays off real-life sword science
Get an inside look at the weapons created for the new season of HBO's "Game of Thrones" series.
By Alan Boyle
All swords are not created equal, particularly when it comes to "Game of Thrones," the HBO series based on George R.R. Martin's character-rich sword-and-sorcery saga. When the series opens its second series on Sunday, some of the swords you'll see are made of cheap resin, others are metal blades just meant to look good ? and a few of them have been custom-crafted using a technique reminiscent of the story's fictional, magic-laden Valyrian steel.
For Martin, swords are serious business.
"The one thing I can say is that he is very, very knowledgeable about history, including weaponry," said Chris Beasley, the proprietor of Valyrian Steel, the Michigan-based company that produces licensed replicas of "Game of Thrones" swords. "When designing the swords, and he is highly involved in the design process of our book replicas, he doesn't want something to look cool. He is more concerned with realism ? who made it, why, and how?"
For example, let's talk about Valyrian steel. In the "Game of Thrones" TV series and Martin's "Song of Ice and Fire" book series, the Valyrian blades were created ages earlier by a vanished civilization, using a blend of alloys forged with magic spells. There's actually a real-life analog, minus the magic, known as Damascus steel. Damascus swords are famous for their resilience and the intricate, flowing patterns that are imprinted on the blades, but the secret of their forging has been lost for centuries.
A few years ago, researchers found that at the microscopic level, Damascus steel contains carbon nanotubes ? structures that seem like 21st-century technological magic dropped into the 17th century. The super-strong nanostructures are mixed in with softer metal in the sword. That solves the classic dilemma of sword-making: how to make a blade that is hard enough to do damage, yet supple enough not to break.
HBO
Young King Joffrey (Jack Gleeson) sits on an Iron Throne made from the swords of enemies.
Modern-day Valyrian steel
Today, swordsmiths use a process known as "pattern welding" that produces results similar to the lost art of Damascus steel. Multiple layers of steel, with different amounts of carbon and other elements, are forge-welded together to create a blade that combines strength and suppleness. When all the layers of metal are flattened and folded together, over and over, it's like having two blades ? or, more accurately, 200 blades ? in one.
Some of the best-known Valyrian blades seen in the "Game of Thrones" TV series, such as the swords nicknamed Ice and Longclaw, were made using the pattern-welding technique.
"Ice was the main weapon to get right," Tommy Dunne, the weaponmaster for the series, said in a Westeros.org interview. "From the concept to the construction, it was about three weeks to make, as the blade was hand-forged by pattern welding, and the blade was drawn using machine hammers. But as with any good weapons, there's some other secrets that will remain secret!"
Beasley's business also sells some swords made with pattern-welded steel. "Those could technically be used, but we never recommend it," he told me. "Our swords are limited-edition collectibles, and no sword is impervious to damage. If used, they will get nicks, and chips, and scratches."
Beasley recalls that Valyrian Steel's Longclaw replica originally sold for $600, but after the swords were sold out, one customer reported receiving an offer of $3,000 to $4,000 for his sword. "I wouldn't recommend that anyone risk damage to something so valuable," Beasley told me.
Needle at work
If real fake Valyrian steel is too expensive for your taste, you can shell out $170 for Needle, the kid-sized sword that 9-year-old Arya Stark learns to uses with deadly effect in "Game of Thrones." Beasley said Martin had a hand in designing the replica.
"Reading the books, I and many others thought, 'OK, this is a small rapier,'" Beasley recalled. "George very quickly put that notion to rest. He said that Mikken, the Winterfell smith who made it, would never have seen a rapier in his life, so how could he make one? That is why the book version of needle is more or less a small, slim longsword, and not a rapier."
Martin was so pleased with the result that he had one of Valyrian Steel's Needles sent to the actress who plays Arya so she could practice with it. And she's not the only one.
"One customer did tell us that they use Needle in their offhand to increase strength and coordination," Beasley told me. "They keep it in their office, and when on the phone or otherwise occupied they just jab and thrust with their left hand." (Remind me not to burst into that office unexpectedly.)
New twists in an old trade
Some of the secrets from the golden age of swordsmithing may have been lost over the past few centuries, but technology is adding new twists to the trade. There's been a lot of research into the use of alloying elements such as carbon, manganese, chromium, nickel, titanium and molybdenum. Materials scientists also are developing metallic materials infused with carbon nanotubes, just like in the good old days of Damascus steel.
"In more modern times, steel can be precisely made, and the overall material creation process can be more scientific so that you can get precisely the steel with the hardness and flexibility you desire," Beasley said. "So materials science has probably made modern swords stronger than older ones, but construction methods have not changed ? though, obviously, power tools and other equipment have replaced arm power."
Ah, power tools ? I'll bet the swordsmiths of King's Landing would have shelled out hundreds of silver stags for a good belt grinder. Are you in a mood to geek out over the science and technology of "Game of Thrones"? Feel free to indulge yourself in the comment section.
More angles on 'Game of Thrones':
Alan Boyle is msnbc.com's science editor. Connect with the Cosmic Log community by "liking" the log's Facebook page, following @b0yle on Twitter or adding Cosmic Log's Google+ page to your circle. You can also check out "The Case for Pluto," my book about the controversial dwarf planet and the search for other worlds.
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Deloitte to Acquire HR Technology Consultancy, Aggressor ...
NEW YORK, March 29, 2012 /PRNewswire/ --?Deloitte has signed a definitive agreement to acquire substantially all of the assets of Aggressor LLC, a leading business and IT consulting firm that focuses exclusively on providing deployment services for Workday solutions. Workday is a leader in software as a service (SaaS) enterprise solutions for global human resources (HR), payroll and financial management.
The acquisition elevates Deloitte as the leader in Workday HR and finance consulting services for both transformational and technology-only deployments. Moreover, the acquisition further strengthens Deloitte's market position as the leading HR technology and transformation consulting practice based on breadth and depth of capabilities, as rated by Kennedy Consulting Research & Advisory.(1)
Global companies are using Workday's human capital management, talent management, payroll, financial management and spend management solution to help acquire, measure, develop, deploy and retain their global workforce, as well as help improve financial and operational efficiencies and gain greater insights into their organizations.
Deloitte's Human Capital Trends 2012 report concludes that transformative technologies, such as cloud, are driving many companies to focus on advancing their HR capabilities.
"With this acquisition, Deloitte broadens its HR transformation capabilities.? As a result, we have strengthened our position to be the leading provider of Workday solutions, helping our clients keep pace with innovation to lead their organizations into the future," says Barbara Adachi, national managing director of Deloitte Consulting LLP's human capital consulting practice.?
Based in Pleasanton, Calif., Aggressor complements Deloitte with top talent that can help Deloitte firmly grow and maintain its leadership position in the HR transformation market. ?Approximately 100 Aggressor employees are expected to join Deloitte's human capital consulting practice as part of its HR transformation service line.
"By uniting our demonstrated Workday delivery approach with Deloitte's unmatched human capital experience and global reach, our new practice will offer clients a broad array of Workday-enabled services ranging from technology-driven system deployments to global HR transformation," says David Hom co-founder of Aggressor. ?"We are thrilled that by bringing leading talent from both teams we can help our clients get even more from their Workday investment."???????????
Workday co-founder and co-CEO Aneel Bhusri added,?"We are excited about the combination of Deloitte and Aggressor, two leading Workday solution providers. We believe that our clients will benefit tremendously from the combined strength of Aggressor's Workday capability and Deloitte's leading HR transformation practice."
The transaction is expected to close in April.
About Deloitte's Human Capital practice
Deloitte helps organizations effectively manage their human capital to drive business growth. ?It does this by leveraging advanced analytics to develop talent management and business-driven HR strategies to deliver results.? Deloitte is a leader in human capital consulting, bringing a combination of business, industry and HR knowledge, supported by the breadth of services and capabilities of a multidisciplinary professional services organization and being part of the global network of Deloitte Touche Tohmatsu member firms.? For more information, please visit http://www.deloitte.com/humancapital.
As used in this document, "Deloitte" means Deloitte Consulting LLP, a subsidiary of Deloitte LLP. Please see www.deloitte.com/us/about for a detailed description of the legal structure of Deloitte LLP and its subsidiaries. Certain services may not be available to attest clients under the rules and regulations of public accounting.
(1) The Kennedy Vanguard of HR Technology & Transformation Consulting Practices, 2010
Source: Kennedy Consulting Research & Advisory; HR Technology & Transformation Consulting Marketplace 2010-2013; ? Kennedy Information, LLC.? Reproduced under license.
SOURCE Deloitte
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Softrix: A complete web solution for your business | Blog - Softtrix ...
Every new or existing business needs an attractive website, and every website requires more and more traffic to increase the sales revenue of the company. Designing and developing a website is the first step of starting your business online and you require professional help for it. You can find various web developers but the problem is not all of them provide complete package. I mean some of them will only design it for you while others will only offer promotion. You might be wondering if there is any company which offers all of it! Yes, Softrix is a company that can provide you a complete web solution. It?s a company that provides professional web design and internet marketing services for every kind of business.
business web solution
Softrix have highly skilled web designers for high quality web pages, no matter what business you are in to they will customize the designs according to your requirement. The company also deals with storefronts and corporate pages. The design team of Softrix has stunning unique ideas that can distinguish your website from all other similar businesses on the Internet. They also make sure that your website interface is user friendly so that your clients can have easy access to all the services you offer. The working of the webpage is guaranteed by the professional web development team of Softrix.
Once you will have your website developed, the next step will be to promote it. Getting more traffic to your is really important to increase the sales and revenue of your company. No matter how good your website is, if you don?t promote it you will not get the desired results. That?s why Internet marketing and search engine optimization of the website is an essential task. You can again get assistance of Softrix for this. They are Google Adword certified partners and can provide you the desired traffic for better business online. Every kind of Internet marketing like email, blogging, link building, and search engine optimization is offered by Softrix to its clients for increased traffic.
business website solution
If you are an existing business and not getting enough traffic to your website then you can also consider Softrix. There are several cases where websites are having enough traffic but not the sales revenue. You might be thinking why is that so? Well, it?s because of the fact that many website owners pay for promoting and generating traffic to their website but the companies they choose sometimes generates the useless traffic that is useless for their business. Softrix guarantees genuine traffic that will convert into your potential customers. This will maximize your sales revenue and your business will grow faster.
Source: http://www.softtrix.com/blog/web-design/softrix-a-complete-web-solution-for-your-business/
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Friday, March 30, 2012
Poverty, frustration keep Macedonia tensions alive
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Source: http://news.yahoo.com/poverty-frustration-keep-macedonia-tensions-alive-070505252.html
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Google Drive leaks suggest 5GB free storage, in-app document editing
Google Drive leaks suggest 5GB free storage, in-app document editing originally appeared on Engadget on Fri, 30 Mar 2012 08:43:00 EDT. Please see our terms for use of feeds.
Permalink |
Talk Android, TheNextWeb | Email this | CommentsSource: http://www.engadget.com/2012/03/30/google-drive-leaks/
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Car Audio Accessories and Use | Mobile Audio, Video, Navigation
Auto is not just a vehicle. Many of the cars are owned by their best. You wish them all the best in comfort and luxury. And in order to ensure that they will not attack. Car audio accessories are items that the maximum attention of motorists to get.
Most people listen to music on the go. Few companies are so busy that they listen to music or talk while driving. Because they have a good sound system is essential. Car owners have now been found that in general, to the outside of the vehicle maintain. But experts suspect that the same attention to the interior too.
The technology has its development in all areas. Whether large or small, all uploaded with new features. Rather it is the car cassette player, but now there are multi-purpose systems ..
The market for electronic devices is big as an ocean. Every day a new program with unique features introduced in the market. List of brands and seems to not want to end. And all products are at affordable prices. Actual movement in prices due to market competitiveness. So the best quality raw materials is no big deal.
With such a wide range of different, it is very important that you have the best quality for your vehicle of choice. You can attach CD player in the car with subwoofers. Of the speakers you need to get your car fixed quality to the over-all power to increase. If you install the amplifier for loud music ensures the correct wiring done in the car.
Music can really enjoy if the sound quality of a system is to be good. Music in the car is not only fun but also help you if you open for a long distance, and also the eyes. Then select the name of the system. Not only will you sound but also saves you time and money often recover.
This entry was posted in Audio Video. Bookmark the permalink.Source: http://www.betonted.com/779/car-audio-accessories-and-use
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All About Mesothelioma Cancer | Best And Most Information About ...
Mesothelioma is a fatal disease that can severely affect the health conditions of a person. This is a severe type of cancer. A person has to check out the status of malignant Mesothelioma for the correct treatment of this disease. One has to consider this cancer according to the place of the infection.
Some cases pertaining to this particular disease are highly complex, when one relates the disease to the age of the particular person. The cancer may or may not be severe depending upon the intensity of Mesothelioma in that person. In simple words, this disease depends on the extent of contraction in the body of the person.
Cancer cells vary highly. Thus, the detection of the cancer cells including malignant Mesothelioma is difficult. In most cases, one may not detect Mesothelioma cancer in the early stages resulting in its highly improbable treatment.
The behavior of these cancer cells is quite different in different cases. In Mesothelioma cancer, the person?s lung and abdomen has a higher liability for the initial attack. The cancer cells multiplication may result in significant changes in the chest cavity. Thus, it may prove to be the most dangerous for the respiratory system.
In simple words, Mesothelioma is a form of lung cancer caused due to exposure to Asbestos. The name ?Mesothelioma? is significant of Mesothelial cells, which are am important aspect of the body system. These cells are extremely important for the immune system of the body. Thus, Mesothelioma cancer generally affects the immunity in the body. Mesothelioma shows late symptoms.
Therefore, most of Mesothelioma cases go undetected. One can understand the seriousness of this particular disease only when he/she comes to know about the life expectancy of the person suffering from this particular disease. The life expectancy of Mesothelioma cancer patients is quite alarming for a normal person.
The probability of this disease is high in people ageing more than 40. Malignant Mesothelioma condition reduces the life period of a normal person. Patients suffering from Malignant Mesothelioma live an average period of only less than two years. There are even researches that prove that the number of people suffering from Mesothelioma cancer is going to rise rapidly in the near future. This cancer only affects the Mesothelial tissue in the delicate lining of lungs and other respiratory organs. This type of Mesothelioma is the malignant Mesothelioma.
Another form of Mesothelioma cancer affects the pleura, which is the portion between the lungs and chest. This type of cancer is pleural mesothelioma. However, the reason for this cancer is not always compulsorily, asbestos. Scientific planning is necessary to achieve compensation that is legal financial help in terms of cancer analysis.
If the disease has occurred from asbestos exposure, then asbestos may spread from the person, who initially inhaled asbestos to the healthy person he/she may come in contact. The last type of Mesothelioma cancer is the pericardial Mesothelioma, which affects the heart lining.
On Website, you will find all the required information and details regarding mesothelioma cancer and its various types.
Source: http://www.viedecousu.com/all-about-mesothelioma-cancer.html
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Recording Catches Teachers Mistreating Special Needs Student
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Asbestos Cancer Attorney Mesothelioma Attorneys And Legal ...
Mesothelioma Attorneys And Legal Advice To Help Your Case At Their Best
Article by James Kennedy
For many years, individuals working on demolition sites were exposed to asbestos fibers. These materials were often swallowed into the stomach, and even more found their way into the bottom of the lungs. Other people living nearby to asbestos that was getting mined were also subjected to the silicates, and all of this suggests that there are a high number of people in the country who are subjected to the risks of developing asbestos cancers such as mesothelioma. While the sufferers are looking for compensation for his or her sicknesses from former employers, they might find themselves dealing with a brick wall of resistance from huge businesses.
This can be where it is a sensible plan to employ skilled asbestos lawyers to look into your sickness. It could take between 15 and 50 years for somebody exposed to asbestos to develop a cancer, although they may have earlier lung conditions like pneumonia which could be a caution when the cancer emerges. However, doctors hardly ever realize that their patient is in danger for asbestos cancers unless they develop, and by this time it could be tough to treat the sufferer. More often than not the previous employee and his family will be left seeking compensation that may assist prolong his life for a brief period, however could not be in a position to let him recover from the condition.
In cases where the employee was subjected to asbestos as part of a building clearance in 80s and 90s, the carelessness on the part of the employer is comparatively easy to establish. Before this, the use of asbestos as a building material was still so widespread that actual deliberate exposure could be much tough to prove. Employing asbestos lawyers can help you to establish a claim and then pursue it from the courts successfully.
Speak to asbestos lawyers now regarding your situation. So long as it has been established by a registered physician, then you can start proceedings against earlier employers or site owners for compensation. Even when you only have persistent bronchitis, or other lung problems, then you can want to take out a lawsuit now when the position will become untenable.
Discuss to the lawyer concerning your exposure to the toxic materials, describing any potential witnesses and making a note of anybody living who can help you to determine your claim. These facts could assist your attorney to require the case further, and at least allow him to do a little bit of research into different cases which are claimed against the same company.
About the Author
Get compensation for exposure to Asbestos Cancers today by visiting the website http://www.mesotheliomalawyersattorneyshq.com. Discuss to an attorney regarding your position, and your desire to make a claim for earlier asbestos exposure. Whether you are currently starting your research into Mesothelioma, or want to advance your legal requirements, they make your life easier. Their goal is to make things as streamlined and as easy as possible for you to follow. Visit the website to know more.
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[OOC] Dungeons and Instances
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This forum is for OOC discussion about existing roleplays.
This forum is for OOC discussion about existing roleplays.
Please post all "Players Wanted" threads in the Roleplayers Wanted forum!
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Forum for completely Out of Character (OOC) discussion, based around whatever is happening In Character (IC). Discuss plans, storylines, and events; Recruit for your roleplaying game, or find a GM for your playergroup.Alright, here is where I will be posting dungeons and instances, and their levels, content, etc.
This is a work in progress, and I will edit it soon.
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Buy a House With Bad Credit | adstalker.com
?
Your financial capability can put a dent into your credit score or induce damage filled with stress and disappointments in terms of what you can and can?t do.
Amazingly enough, one thing you can do despite having a bad score is buying a house.
Image Courtesy of?Roger Wollstadt?via Flickr
Obtaining a Loan
The first thing you would like to do when you want to buy a house is to get a loan. The next (and most confounding) question is what type of loan you should be getting. The chances of getting a subprime loan hardly exist in these days. And unfortunately, subprime loans cater to people with shaky credit scores.
The house buying process doesn?t even start until you have accumulated a large down payment. If you don?t, your only other option is to accept a higher interest rate which could hardly be favorable to a person with bad credit. Furthermore, you may even have to wait for a foreclosure or bankruptcy limitation while house shopping.
There are other options to look into, but you should take the time to ask yourself,?is this worth it??Americans are usually reeled under pressure to buying a new house. In your current credit score, do you think that you can?handle?the stress of owning a home?
Finding Security in the Future
Waiting may possibly be the best option for you. Right now, real estate values are both stabilizing and de-stabilizing, which means that the market remains unstable despite leaning towards stability.?If you can wait, you can use the time to focus on fixing your credit. Moreover, it gives you time to both reduce your debt and gain a better credit score?two things that will ultimately save you money once you actually?do?purchase a house.
Weighing Other Options
You?re probably still adamant about buying a house despite knowing the precautionary road ahead. If that?s the case, your best option is to opt for Federal Housing Administration loan insurance.
Helping millions to qualify for loans and secure home mortgages since 1934, FHA takes the risk if the borrower defaults. It will help you to buy your first home even if you have pre-existing financial problems, such as a low down payment and a negative credit history. While you do have to show you?re financially responsible, you will not be discounted for past misdemeanors.
Other options, such as finding a seller who will carry a note or even going for a subprime loan, do not look particularly good in the market these days.
Taking the First Step
Your best bet is to obtain a copy of your credit report to know where you stand. If it doesn?t look good, try to fix it first before house shopping. Remember, the better the score, the less debt you?re going to find yourself in.
So plan accordingly to your best advantage. Owning a home may take up to a year or two, but knowing where to start will gear you with strategies on?how?to get?to where you want to go and prepare you for any possibilities.
I am a full time business owner, part time blogger, and life long student of all things related to money, finance, and entrepreneurship. Read more about Michael or contact him. Connect with me on Twitter, Facebook, and google+.has blogged 108 posts here.
Source: http://www.adstalker.com/personal-finance/can-you-buy-a-house-with-bad-credit/
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US top court wrestles with final health law hearings
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Thursday, March 29, 2012
Video: Young veterans share their skills, dreams
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Source: http://www.msnbc.msn.com/id/21134540/vp/46878715#46878715
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Green Day's Reign On Shaky Ground In Musical March Madness
Evanescence and Paramore battle it out in the first #1 vs. #2 matchup in MMM history; Elite Eight voting ends tonight at midnight ET!
By James Montgomery
Green Day's Billie Joe Armstrong
Photo: Getty Images
There are still a few hours left before polls close in the Elite Eight of MTV's Musical March Madness, and it looks like every second — and vote — is going to count. Because, as we predicted on Wednesday, we've got more than a few epic encounters on our hands, as the remaining eight bands slug it out for a spot in the Final Four.
And, really, with matchups that include Paramore vs. Evanescence, Green Day vs. Adam Lambert and the MMM grudge match to end all MMM grudge matches (that would be Coheed and Cambria vs. Tokio Hotel), well, we'd expect nothing less. Things have been wild, to say the very least.
And so, with Elite Eight polls closing tonight at midnight ET, we figured we'd bring you up to date on all the back-and-forth battles. And they're basically all back-and-forth battles at this point. Shoot, even the My Chemical Romance/Metallica tilt seems destined to come right down to the wire. So here's where we stand with just a few precious hours left.
East
We thought the MCR/Metallica matchup had the potential to be a blowout, and for a while, it looked like those predictions would be correct: MMM heavyweights My Chem surged to a huge lead over road-weary Metallica, though, as the hours wore on, Hetfield and company dug deep, and have been staging a furious comeback ever since. As of this afternoon, they still trail MCR by a fairly sizable amount (something like 12,000 votes), but the gap is closing by the minute. Do they have enough left in the tank to overtake My Chem, or will Gerard and the boys make MMM history and advance to their third-straight Final Four? We'll just have to wait and see.
West
There's a huge upset brewing out West, as #11 Adam Lambert has got defending MMM champs Green Day on the ropes. Somewhat surprisingly, this matchup has seen more votes cast than any other in the Elite 8, as the Glambert Nation has shown up in full to support their man. Barring a tremendous rally, it looks like Green Day are going to have to relinquish the trophy, which, given the fact they never bothered to pick it up in the first place, should actually be quite easy. Sort of like Lambert's dominance up to this point.
East
The biggest MMM rematch in years — 2010 champs Coheed and Cambria once again facing off against eternal MMM bridesmaids Tokio Hotel, in a battle wrought with historical tension — has, instead, turned into a massacre. Though fans of both bands have been lobbing accusations of cheating (as much a MMM tradition as the trophy itself, it would seem), we've been monitoring this one closely ... and, Tokio fans, you're seemingly home free. With hours left, Tokio are pasting Coheed (to the tune of some 440,000 votes) and seem destined to return to the Final Four. Then again, as we've learned in the past, you can't count Coheed's Children of the Fence out — but sufficed to say, they've got their work cut out for them if they want to help their favorite band advance. Just keep it clean, folks.
Vote for your favorite band, discuss and share on Facebook and Twitter in the MTV Musical March Madness interactive bracket!
South
The first #1 vs. #2 matchup in Musical March Madness history has most definitely lived up to the advance billing, as top-seeded Evanescence and #2 Paramore have been slugging it out since polls opened. Early on, this one was as close as double digits though, as it stands now — with nearly 2 million votes cast — it's Ev who hold the lead (we see you, Amy Lee!) Does the Para-clan have one more rally left in them, or will Evanescence run the table and become the first-ever #1 seed to make the Final Four? The hour is growing late, though we suspect this one isn't over just yet.
There are just hours remaining in the Musical March Madness Elite Eight! Can you lift your favorite band to the Final Four? Or, alternately, bring them back from the brink? Get voting, time is running out!
MTV's 2012 Musical March Madness tournament reaches the Elite Eight! Voting runs until midnight ET on Thursday, March 29, and winners are determined by fan votes, so if your favorite act is still alive, it'll be up to you to guide them to glory. You can rally the troops on Twitter using the hashtag #MMM or by downloading one of our custom badges — but get ready, it only gets more difficult from here on out.
Related Videos Related Photos Related ArtistsSource: http://www.mtv.com/news/articles/1682056/green-day-musical-march-madness-elite-8.jhtml
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Vitals - Rethinking how we confront cancer: Bad science and risk ...
A new government report found the overall cancer death rate is falling, and the incidence of cancer deaths is declining in men and has leveled off in women. NBC's Robert Bazell reports.
?By Robert Bazell
Chief science and medical correspondent
NBC News
Two thought provoking and disturbing studies out Wednesday raise major questions about conduct of the ?War on Cancer.? One examines? the quality of basic research and the other concludes that half of current cancer deaths could be prevented.
Almost 90 percent of early stage cancer research looking for improved treatments is wrong, according to scientists at biotechnology giant Amgen and the MD Anderson Cancer Center. ?The researchers describe their findings as ?shocking.?
Read Wednesday's news about the decline in cancer death rates.
The allegations about questionable research in the quest for treatments appear in the prestigious journal Nature.? C. Glenn Begley, the former head of cancer research at Amgen, and surgical oncologist Lee M. Ellis of MD Anderson Cancer Center in Houston describe how scientists at the Thousand Oaks, Calif.-based Amgen tried to replicate the results of 53 landmark cancer research papers.? By landmark, they mean papers cited by others as significant progress.? All were so-called ?pre-clinical,? meaning they were studies in rodents or with cells in petri dishes. The scientists were able to replicate only 11 percent of the conclusions.? In science, replication is proof.? If a study can?t be reproduced reliably, it is wrong.?
Most of the papers in question describe gene mutations or other changes in cancer cells that could be potential targets for new cancer treatments.? Such research is obviously critical for companies like Amgen deciding how to spend hundreds of millions testing potential drugs in humans.? The findings at Amgen do not differ greatly from those at a team at Bayer HealthCare in Germany, which reported last year that it could not replicate 25 per cent of studies.
Begley and Ellis assume that fraud plays little or no role in the bad science. ?These investigators were all competent, well-meaning scientists who truly wanted to make advances in cancer research,? they write.
So, what is the problem? Scientists often ignore negative findings that might raise a warning, cherry picking the results and putting the best face on their research. The practice involves many parties -- not just the scientists -- in the research process who turn blind eyes to questionable actions.
As Begley and Ellis detail it, ?To obtain funding, a job, promotion or tenure, researchers need a strong publication record?Journal? editors, reviewers, and grant review committees [and I might add journalists?R.B.] often look for a scientific finding that is simple, clear and complete?a ?perfect? story.? It is therefore tempting for investigators to submit suspected data sets for publication, or even to massage data.??
Whatever the motivation, the results are all too often wrong.
Begley and Ellis call for nothing less than a change in the culture of cancer research.? They demand more willingness to admit to imperfections and an end to the practice of failing to publish negative results.?
?We in the field,? the say, ?must remain focused on the purpose of cancer research: to improve the lives of patients.?
While the Amgen report casts doubt on cancer research, a separate study concludes that fully half of all cancers occurring today are preventable.? It raises questions about the billions spent searching for treatments and concludes that ?we must vigorously implement what we already know about preventing cancer.?
The article about prevention appears in the top-tier journal Science Translational Medicine. Epidemiologists Graham Colditz, Kathleen Wolin and public health researcher Sarah Gehlert of Washington University in St. Louis review the best data.?
According to the careful Washington University study, smoking remains the biggest cancer-causing environmental factor ?-- responsible for ?33 percent of cancer deaths, almost 189,000 lives a year in the U.S. alone.? Obesity now follows closely, causing 20 percent of cancer deaths, or 114,000 people a year.? Pollution and radiation (most of it from medical sources) each account for only about 2 percent of cancers.?
The argument about allocation of funds for reducing the risk of cancer versus treatment is as old as our efforts to confront cancer.? But as these authors show the evidence and the need to act on it grow ever stronger.
As a society, we have shown we can do a great deal ? but not nearly enough ?? about tobacco.?Obesity is another story, but we must do better if we want to be serious about cancer ? and all the other attendant diseases.
Even short of the huge social challenges in confronting tobacco and obesity, there are many proven relatively simple methods to cut cancer deaths.? They include effective screening tests, such as pap tests and colonoscopies. The vaccines against HPV and hepatitis B both prevent cancer-causing viral infections, and aspirin is looking ever better as a cancer control agent.
Only 1.5 percent of the U.S. cancer research budget now goes to risk reduction. The rest seeks to find treatments, an effort that Begley and Ellis show is seriously flawed.? As these two powerful studies out Wednesday show, it is high time we reorder our priorities.
Robert Bazell is NBC's chief science and medical correspondent. Follow him?on?Facebook?and?Twitter.
?Related:
Daily aspirin linked to reduced cancer risk
What kills one person every six seconds??
More from Robert Bazell:??
Could weight-loss surgery end diabetes?
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